Tested and verified to reduce five trace pharmaceuticals, including: ibuprofen, progesterone, atenolol, trimethoprim & fluoxetine. Compatible with select GE side-by-side and bottom-freezer refrigerators. Certified to reduce chlorine-resistant cysts, lead, select pharmaceuticals and 15 other contaminants. Simple design provides easy, tool-free, no-mess filter replacement. Filter cartridge should be replaced every six months or 300 gallons